Question

The presently accepted model of enzyme action was proposed by Daniel Koshland in the 1960s and suggested that the enzyme was a flexible structure with an active site roughly complementary to the substrate that binds it. After its initial interaction with the substrate, the enzyme alters its shape and thus improves the fit of the substrate in the active site) What is the name of this model?

1) The Induced Fit model
2) The Flexible Sponge model
3) The Lock and Key model
4) The Koshland model
5) The Flexible Fit model

Answer 1

The name of the model proposed by Daniel Koshland that describes enzymes as flexible structures that change shape upon substrate binding is the Induced Fit model.

Step-by-step explanation:

The presently accepted model of enzyme action proposed by Daniel Koshland in the 1960s is known as the Induced Fit model. This model describes how enzymes change shape upon substrate binding, confirming that enzymes are not rigid structures, but rather are dynamic and can adapt their shape to better interact with substrates.

Unlike the lock-and-key model, where the enzyme's active site and substrate fit together without any shape alteration, the induced fit model allows for a more accurate representation of the dynamic nature of enzyme-substrate interaction. This flexibility is essential for the enzyme to catalyze its reaction optimally, as it ensures that the enzyme and substrate are properly aligned to facilitate the chemical reaction.