Question

Effector memory T cells can be distinguished from the central memory T cells from which they arise by?

1) Their life-span
2) CD45RA
3) CCR7
4) CD3
5) IL-4 secretion

Answer 1

Effector memory T cells and central memory T cells can be distinguished by the expression of CD45RA. (option 2)

Step-by-step explanation:

Effector memory T cells and central memory T cells can be distinguished by the expression of CD45RA. Central memory T cells typically express high levels of CD45RA, whereas effector memory T cells, derived from central memory T cells, downregulate CD45RA expression. CD45RA is a surface marker associated with naive T cells, and its downregulation marks the transition from central memory to effector memory T cells. This differentiation is crucial in understanding T cell populations and their functional characteristics in immune responses.

The modulation of CD45RA expression serves as a phenotypic marker for T cell differentiation stages, allowing researchers and immunologists to identify and characterize distinct T cell subsets. This distinction aids in studying immune responses, vaccination strategies, and the development of targeted therapies.

The expression of CD45RA provides a clear distinction between effector memory T cells and their central memory counterparts, offering insights into the phenotypic changes associated with T cell differentiation. Understanding these distinctions is essential for unraveling the complexity of immune responses and designing effective immunotherapeutic approaches.