221k views
2 votes
A mutation that renders the MHC class II molecule HLA-DM nonfunctional would likely lead to:

1) cells unable to synthetize MHC class II molecules.
2) cells with no HLA-DO.
3) cells with MHC class II molecules only bound with CLIP.
4) cells with class II MHC bound with a variety of self-antigens.
5) a deficiency in CD8+ T cells.

1 Answer

4 votes

Final answer:

A nonfunctional HLA-DM would result in MHC class II molecules being bound only with CLIP, hindering the antigen presentation process and weakening the immune response.

Step-by-step explanation:

A mutation that renders the MHC class II molecule HLA-DM nonfunctional would likely lead to cells with MHC class II molecules only bound with CLIP. HLA-DM plays a critical role in the MHC class II antigen presentation pathway by facilitating the release of the invariant chain peptide, CLIP, from the MHC class II molecule. Without functional HLA-DM, CLIP cannot be efficiently released, preventing the binding of other peptides, including pathogen-derived antigens, to MHC class II. As a result, T cells cannot be effectively activated, compromising the immune response.

User Adnrw
by
8.4k points
Welcome to QAmmunity.org, where you can ask questions and receive answers from other members of our community.

9.4m questions

12.2m answers

Categories