Question

Which of the following is a characteristic of follicular dendritic cells in the primary folLiCles of secondary lymphoid tissues?

1) They are bone marrow derived hematopoietic cells.
2) They provide a stable depository of intact antigens able to bind to B-cell receptors.
3) They internalize immune complexes through CR2 receptor cross-linking.
4) They produce cytokines that induce B cells to proliferate and become centroblasts.
5) They express large amount of MHC II molecules to present antigens to B-cells

Answer 1

The characteristic of follicular dendritic cells in the primary follicles of secondary lymphoid tissues is that they serve as a reservoir of 2) intact antigens binding to B-cell receptors.

Step-by-step explanation:

The characteristics of follicular dendritic cells (FDCs) in the primary follicles of secondary lymphoid tissues reflect their unique role in the immune response. Among the options provided, FDCs are indeed responsible for preserving intact antigens, which are then able to bind to B-cell receptors. This is option 2: They provide a stable depository of intact antigens able to bind to B-cell receptors. FDCs are not bone marrow-derived hematopoietic cells, as they arise from different cell lineages not associated with hematopoiesis. They also do not internalize immune complexes through CR2 receptor cross-linking, nor do they produce cytokines that induce B cells to proliferate into centroblasts. The expression of large amounts of MHC II molecules is typically characteristic of antigen-presenting cells like macrophages or B cells, not FDCs.