Final answer:
Various F-actin regulators contribute to cell migration process, including Rho-family small GTPases, substrate stiffness, and focal adhesions.
Step-by-step explanation:
The process of cell migration is regulated by various F-actin regulators. One important regulator is the Rho-family small GTPases, which act as molecular switches to control actomyosin system assembly and activity.
For example, Rho-signaling in mature adhesions up-regulates actin polymerization and contractility of non-muscle myosin II motors. Another regulator is substrate stiffness, which can affect cytoskeletal order and myofibril assembly, ultimately impacting cell migration. Additionally, focal adhesions play a critical role as mechanical linkers and signaling centers, activating biochemical signaling molecules that regulate cell migration, differentiation, and fate.