Question

What is the role of CCR5Δ32 in HIV co-receptor truncation?

1) It competes with HIV in binding to CCR5
2) It enhances the binding of HIV to CCR5
3) It has no effect on the binding of HIV to CCR5
4) It prevents the binding of HIV to CCR5

Answer 1

CCR5Δ5Δ32 mutation results in a truncated receptor that prevents HIV from binding to CCR5 on T cells, thereby blocking viral entry and conferring resistance to infection.

Step-by-step explanation:

The role of CCR5Δ5Δ32 in HIV co-receptor truncation is that it prevents the binding of HIV to CCR5. People with this mutation produce a truncated version of CCR5 on the surface of T cells to which HIV cannot effectively bind, thereby blocking the viral entry into the host cells. Moreover, this mutation has led to new research avenues, such as the development of drugs that inhibit the binding of HIV to CCR5, which is a crucial mechanism in HIV virulence and infection.