Final answer:
To date a pregnancy when the LMP is unknown, an ultrasound measurement of the crown-rump length is considered the most accurate method, particularly between the 7th and 13th weeks of gestation.
Step-by-step explanation:
The best way to date a pregnancy when periods have been irregular and the last menstrual period is unknown is through an ultrasound measurement, specifically, the crown-rump length (CRL). While both qualitative and quantitative serum hCG tests can confirm pregnancy, they do not provide precise gestational age. The uterine size on pelvic exam is a less precise method for dating a pregnancy compared to ultrasound. CRL is considered the most accurate method to date pregnancy between 7 and 13 weeks gestation.