Final answer:
Prostaglandin synthetase inhibitors effectively delay or prevent premature labor by blocking the production of prostaglandins that stimulate uterine contractions.
Step-by-step explanation:
Prostaglandin synthetase inhibitors are a class of drugs that work as tocolytics by inhibiting the synthesis of prostaglandins, which are compounds that stimulate uterine contractions and thus promote labor. By blocking the action of enzymes like cyclooxygenase (COX-1 and COX-2), these inhibitors reduce the production of prostaglandins (especially PGE2 and PGF2α) that enhance uterine muscle contraction.
During pregnancy, a decrease in prostaglandin synthesis eases uterine contractions, which can delay or inhibit premature labor. These inhibitors include nonsteroidal anti-inflammatory drugs such as aspirin and ibuprofen. The effect of blocking prostaglandin synthesis goes beyond tocolysis, incorporating varied responses such as pain relief and reducing inflammation, as these biochemicals are also involved in the modulation of pain and fever.