Final answer:
To ripen the cervix at 42 weeks gestation with a long and closed cervix, a Prostaglandin E1 tablet should be used. Oxytocin infusion is not optimal for cervical ripening, and RU486 is not indicated for this purpose.
Step-by-step explanation:
The appropriate method to ripen the cervix in a 22-year-old G1 who presents at 42 weeks gestation with a long and closed cervix is using a Prostaglandin E1 tablet. Artificial rupture of membranes and membrane stripping are generally used when the cervix is more favorable. An oxytocin infusion may be used to stimulate contractions but is not the best option for cervical ripening. RU486 is a progesterone antagonist typically used for medical abortions, not cervical ripening in a term pregnancy.