Final answer:
Differences in the number of protein coding genes explain most of the variation in genome size.Hence, the correct answer is option 1.
Step-by-step explanation:
The considerable variation in genome size can be explained by a variety of factors. However, the most significant factor is differences in the number of protein coding genes. While there is no correlation between genome size and the number of genes coded, the presence of more protein coding genes can contribute to a larger genome size. Other factors, such as differences in the number of ribosomal RNA genes, pseudogenes, and mobile genetic elements, can also contribute to genome size variation, but they are not the primary explanation.