Final answer:
An amplification of a signal can occur when the activated GPCRs cause Gα to separate from Gβ and Gγ, leading to the activation of multiple proteins in the cell.
Step-by-step explanation:
Yes, an amplification of a signal can occur when the activated GPCRs cause Gα to separate from Gβ and Gγ. This is because the Gα subunit, when activated, can go on to activate other proteins in the cell, leading to a cellular response. The dissociation of Gα from Gβ and Gγ allows for multiple Gα subunits to activate different proteins, resulting in signal amplification.