Final answer:
A case-control study is the best study design for examining a rare disease as it allows researchers to compare cases with controls and identify potential risk factors or associations with the disease.
Step-by-step explanation:
The best study design for examining a rare disease would be a case-control study. In a case-control study, a group of subjects with the disease (cases) is compared with a group of similar subjects without the disease (controls). This type of study is especially useful for studying rare diseases because it allows researchers to compare the characteristics and behaviors of cases and controls to identify potential risk factors or associations with the disease.