Final answer:
The principle of autonomy is most relevant to the scenario of administering medication without informed consent as it directly relates to a patient's right to make informed decisions about their healthcare.
Step-by-step explanation:
The principle of autonomy is most closely related to the idea that patients must be allowed to make informed decisions about their own healthcare. Therefore, the clinical situation where the principle of autonomy would have the greatest bearing is administering medication without informed consent. This is because informed consent is a critical aspect of respecting a patient's autonomy, allowing them to understand the risks, benefits, and alternatives to the medication being proposed, and to make their own decision about whether to proceed with that treatment.