Final answer:
The only curative treatment for primary hyperparathyroidism (PHPT) is a surgical intervention known as parathyroidectomy. It involves the removal of overactive parathyroid glands, which directly addresses the overproduction of PTH, in contrast to other treatments like bisphosphonates that manage symptoms without curing the disorder. Option c is the answer.
Step-by-step explanation:
The only curative treatment option for primary hyperparathyroidism (PHPT) is parathyroidectomy. This is a surgical procedure where one or more of the parathyroid glands are removed. Parathyroid hormone (PTH) plays a crucial role in calcium regulation by activating osteoclasts, increasing intestinal absorption of calcium, and reducing the excretion of calcium by the kidneys. When PTH levels are abnormally high, as in PHPT, these effects are exaggerated, leading to complications such as brittle bones. Unlike bisphosphonates, which decrease osteoclast activity and are often used in the treatment of conditions like Paget's disease, parathyroidectomy addresses the source of the overproduction of PTH, offering a potential cure.