Final answer:
Sexual side effects are a significant effect of SSRIs that can decrease medication adherence.
Step-by-step explanation:
A significant effect of Selective Serotonin Reuptake Inhibitors (SSRIs) that can decrease medication adherence includes sexual side effects. SSRIs, such as Prozac and Zoloft, are commonly used to treat depression by increasing the levels of serotonin in the central nervous system. However, one of the common side effects of SSRIs is a decrease in sexual desire, which can make some patients less likely to adhere to their medication regimen.