72.1k views
3 votes
What is taking place in Dubin-Johnson disease that causes hepatic jaundice because of bilirubin transport disturbances?

a) Impaired bilirubin conjugation
b) Defective bilirubin uptake
c) Decreased bilirubin excretion
d) Enhanced bilirubin metabolism

User Affian
by
7.1k points

1 Answer

1 vote

Final answer:

In Dubin-Johnson disease, hepatic jaundice occurs due to decreased bilirubin excretion, resulting from a genetic defect in the liver's ability to transfer conjugated bilirubin into the bile.

Step-by-step explanation:

In Dubin-Johnson disease, the condition that causes hepatic jaundice due to bilirubin transport disturbances is c) Decreased bilirubin excretion. Dubin-Johnson syndrome is a rare genetic liver disorder characterized by an impairment of the liver's ability to transfer conjugated bilirubin into the bile. As a result, despite normal liver enzyme activities, conjugated bilirubin accumulates in the liver and subsequently in the bloodstream, leading to jaundice. This accumulation is not due to a defect in bilirubin conjugation or uptake, nor is it the result of enhanced bilirubin metabolism. Instead, it involves a defect in the excretion of conjugated bilirubin into the biliary system.

User Lighter
by
8.3k points