Question

Reference values for unconjugated bilirubin in serum are typically in the range of:

a) 0.1-0.5 mg/dL
b) 0.6-1.2 mg/dL
c) 1.3-2.0 mg/dL
d) 2.1-3.0 mg/dL

Answer 1

The typical reference values for unconjugated bilirubin in serum are 0.6-1.2 mg/dL. Maintaining normal levels is important to avoid complications such as jaundice and kernicterus, particularly in newborns with immature liver function.

Step-by-step explanation:

Reference values for unconjugated bilirubin in serum are typically in the range of 0.6-1.2 mg/dL, which corresponds to option b). Unconjugated bilirubin is a form of bilirubin that has not yet been processed by the liver for excretion. Normal levels are essential, as elevated levels of unconjugated bilirubin, such as in conditions like Crigler-Najjar syndrome and Gilbert's disease, can lead to serious complications like jaundice and kernicterus. It's important to note that the normal concentration of bilirubin in the blood should be less than 1 mg/100ml (<17.1 µmol/L), and excess levels indicate hyperbilirubinemia. When levels reach over 25 mg/100 ml, they may exceed the binding capacity of albumin, leading to potential neurological damage in infants.