Question

What disease is a deficiency in albumin that causes pre-conjugation transport failure, leading to hepatic jaundice because of bilirubin transport disturbances?

a) Gilbert's syndrome
b) Dubin-Johnson syndrome
c) Rotor syndrome
d) Crigler-Najjar syndrome

Answer 1

Crigler-Najjar syndrome is the disease that causes pre-conjugation transport failure and hepatic jaundice due to bilirubin transport disturbances.

Step-by-step explanation:

The disease that is a deficiency in albumin that causes pre-conjugation transport failure, leading to hepatic jaundice because of bilirubin transport disturbances is Crigler-Najjar syndrome. This syndrome is characterized by the absence of UDP glucuronyl transferase activity in the liver cells, which prevents the conjugation and excretion of bilirubin. There are two types of Crigler-Najjar syndrome, Type I and Type II, each with different levels of enzyme activity.