Final answer:
Diffuse Large B-cell Lymphoma (DLBCL) has two main pathological features: large abnormal B cells visible under a microscope and an aggressive growth pattern leading to quick enlargement of lymph nodes. It's the most common subtype of non-Hodgkin lymphoma and primarily affects B cells.
Step-by-step explanation:
Diffuse Large B-cell Lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and has several key pathological features. Two central characteristics are:
- The presence of large abnormal B cells when examined under a microscope. These cells are atypically large compared to normal lymphocytes and can be seen in lymphoid tissues.
- A pattern of rapid and aggressive growth, which can lead to fast enlargement of lymph nodes and involvement of extranodal sites. This aggressiveness underscores the importance of early detection and treatment for a favorable prognosis.
DLBCL affects B cells, causing them to grow uncontrollably and form tumors in lymph nodes and potentially in other tissues throughout the body. Without treatment, DLBCL can be fatal, but with timely intervention, about 70% of patients can achieve a cure.