Final answer:
Creatinine clearance is calculated using the formula: (Urine creatinine × Urine flow rate) / Serum creatinine. It's a crucial measure for assessing kidney function, particularly the glomerular filtration rate.
Step-by-step explanation:
The calculation of creatinine clearance (CC) is instrumental in measuring the glomerular filtration rate (GFR), which reflects the kidneys' ability to filter blood. The creatinine clearance can be calculated using the following formula, where Urine creatinine (U) is the concentration of creatinine in urine, Urine flow rate (V) is the volume of urine excreted per unit time, and Serum creatinine (B) is the concentration of creatinine in blood plasma
(Urine creatinine × Urine flow rate) / Serum creatinine
This formula can be further adjusted for body surface area (BSA) to provide a standardized measurement. The correct calculation of creatinine clearance is crucial for assessing kidney function, and the formula utilized is
CCr = (U × V) / B
It is essential to note that U and V are measured over a period, typically 24 hours, to garner accurate results for comparison. For a final answer in a two line explanation, creatinine clearance helps in determining kidney function by calculating the rate at which the kidneys can clear creatinine from the blood.