Final answer:
The nurse should instruct the client to take phenytoin on an empty stomach and swallow the extended-release capsules whole.
Step-by-step explanation:
The nurse should make the statement to the client: A. Take the medication on an empty stomach. Phenytoin should be taken on an empty stomach to maximize absorption and prevent interactions with food. Taking it with food or grapefruit juice can decrease the medication's absorption and effectiveness. Additionally, phenytoin is available in extended-release capsules which should be swallowed whole and not chewed for faster absorption.