Final answer:
Nesiritide is the drug that reduces peripheral resistance to help the heart pump more efficiently, particularly in patients with heart failure. Loop diuretics like Furosemide are used to treat hypertension and heart failure by increasing urination but do not primarily reduce peripheral resistance.
Step-by-step explanation:
The drug that reduces peripheral resistance, which allows the heart to empty better, particularly in patients who are rehospitalized for heart failure, is Nesiritide (option D). Nesiritide is a vasodilator that works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while decreasing its workload. It is particularly prescribed when patients do not respond adequately to ACE inhibitors and diuretics. Nesiritide helps reduce symptoms of heart failure and can slow certain types of arrhythmias, such as atrial fibrillation.
Loop diuretics, like Furosemide (option B), are another class of drugs used to treat hypertension and heart failure by influencing the loop of Henle's reabsorption of Na+ and Cl- ions. They contribute to increased urination, which in turn helps reduce fluid overload, an issue in heart failure. However, they do not specifically target peripheral resistance as part of their primary mechanism of action.