Question

Inhibition of what enzyme results in relaxation of arteries and ultimately decreased cardiac workload?

A) Angiotensin-converting enzyme (ACE)
B) Phosphodiesterase (PDE)
C) Carbonic anhydrase
D) Aldosterone

Answer 1

Inhibition of the enzyme Phosphodiesterase (PDE) leads to the relaxation of arteries and reduction of cardiac workload by facilitating vasodilation.

Step-by-step explanation:

Inhibition of the enzyme Phosphodiesterase (PDE) results in relaxation of arteries and ultimately decreased cardiac workload. Specifically, inhibiting PDE type 5 can increase blood flow and allow vasodilation to occur. While Angiotensin-converting enzyme (ACE) plays a role in the vasoconstriction pathway by converting angiotensin I to angiotensin II, which causes blood vessels to constrict, it's the PDE enzyme that when inhibited, leads to the opposite effect - vasodilation and reduced workload on the heart.