Final answer:
The statement is true; actin filaments exhibit differential critical concentration (Cc) at the plus and minus ends, leading to a process known as treadmilling, where subunits add and lose at opposite ends resulting in a steady state movement.
Step-by-step explanation:
The statement 'Understand differential Cc on the plus and minus end of MFs and treadmilling' refers to the intrinsic property of actin filaments, also known as microfilaments (MFs), in the cellular cytoskeleton. This process is based on polymerization and depolymerization dynamics which is characterized differently at the plus (barbed) and minus (pointed) ends of the filaments.
Actin filaments undergo a process called 'treadmilling', where there is a continuous addition of actin monomers at the plus end (barbed end) and a concomitant loss at the minus end (pointed end). This results in a constant turnover of subunits and thus, a movement of the filament that resembles a treadmill. The critical concentration (Cc) of actin monomers required for polymerization at the two ends is different, being lower at the plus end than at the minus end, which explains why actin subunits can add to the plus end of a filament while simultaneously detaching from the minus end.
Differential Cc leads to this phenomenon because when the concentration of free actin monomers is between the two critical concentrations, filaments will elongate at the plus end and shrink at the minus end, resulting in no net change in length but rather a shift in position while maintaining a steady state.