Question

What is the GBS treatment regimen if the patient is PCN allergic and at risk for anaphylaxis?

a) Clindamycin
b) Vancomycin
c) Gentamicin
d) Erythromycin

Answer 1

For a penicillin-allergic patient at anaphylaxis risk, vancomycin is the recommended GBS treatment, perhaps combined with gentamicin for a synergistic effect, depending on local antimicrobial resistance patterns.

Step-by-step explanation:

If a patient is allergic to penicillin and at risk for anaphylaxis, the GBS (Group B Streptococcus) treatment regimen recommended is to administer vancomycin. While options such as clindamycin and erythromycin can be considered, their use would depend on the susceptibility of the GBS isolates. In instances where high-level resistance to clindamycin or macrolides is documented or cannot be excluded, vancomycin would be the preferred treatment. Gentamicin may also be used in combination with vancomycin to provide a synergistic effect. It’s crucial that healthcare providers adhere to current guidelines and hospital policies, taking into account local antimicrobial resistance patterns when managing patients with GBS infections.