Final answer:
Prostaglandin E inhibitors like Indomethacin promote the closure of the ductus arteriosus in premature birth.
Step-by-step explanation:
Prostaglandin E (PGE) inhibitors such as Indomethacin promote closure of the ductus arteriosus in a premature birth. When the ductus arteriosus fails to close, it results in blood flowing from the higher pressure aorta into the lower pressure pulmonary trunk, which increases pulmonary pressure and makes respiration difficult. Nonsteroidal anti-inflammatory drugs like Indomethacin can block the synthesis of prostaglandin E2, which is responsible for maintaining the vessel in an open position.