Question

The rationale for NMDA receptor antagonists involves modulation of:

a) Dopamine release
b) Glutamate signaling
c) Serotonin synthesis
d) Acetylcholine release

Answer 1

The rationale for NMDA receptor antagonists involves modulation of glutamate signaling. NMDA receptors are a subtype of ionotropic glutamate receptors, and they are involved in processes like learning, memory, and synaptic plasticity. NMDA receptor antagonists block the action of glutamate on these receptors, which can help prevent excitotoxicity.

Step-by-step explanation:

The rationale for NMDA receptor antagonists involves modulation of glutamate signaling. NMDA receptors are a subtype of ionotropic glutamate receptors, and they are involved in processes like learning, memory, and synaptic plasticity. NMDA receptor antagonists block the action of glutamate on these receptors, which can help prevent excitotoxicity, a process associated with disorders such as stroke, schizophrenia, and epilepsy.