Final answer:
The combination of hydralazine plus nitrates is indicated for heart failure with reduced ejection fraction to alleviate symptoms and improve heart function.
Step-by-step explanation:
The combination of hydralazine and nitrates is indicated for C. Heart failure with reduced ejection fraction (HFrEF). This combination is used to treat or improve symptoms of cardiovascular conditions, particularly heart failure. While hydralazine acts as a vasodilator to reduce the workload on the heart by lowering systemic resistance, nitrates aid in this process by dilating the veins, thereby reducing the amount of blood returned to the heart, which can be particularly beneficial in patients with HFrEF. This therapeutic approach is indicated when a patient is intolerant to ACE inhibitors or ARBs, or as an adjunct therapy to further reduce symptoms in patients already being treated with ACE inhibitors, beta blockers, and diuretics.