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What are the consequences of ischemia in the context of the blood-brain barrier (BBB)?

a) BBB disruption, inflammation, & oxidative stress
b) Enhanced BBB integrity
c) Reduced leukocyte infiltration
d) Decreased apoptosis and autophagy

User Krizzzn
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Final answer:

Ischemia in the context of the blood-brain barrier (BBB) can result in BBB disruption, inflammation, and oxidative stress, as well as reduced leukocyte infiltration and decreased apoptosis and autophagy.

Step-by-step explanation:

Ischemia in the context of the blood-brain barrier (BBB) can have several consequences. The blood-brain barrier can be disrupted, leading to increased vascular permeability and allowing substances to enter the central nervous system that wouldn't normally be able to. This disruption can result in inflammation and oxidative stress in the brain. Ischemia can also lead to reduced leukocyte infiltration, meaning that fewer white blood cells are able to pass through the BBB. Additionally, decreased apoptosis and autophagy, which are cell death processes, may occur due to reduced blood flow and oxygen supply to the brain.

User Daoming Yang
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