Final answer:
The Controlled Substances Act established the classification system for potentially abusive drugs based on their abuse and dependence risk. Passed in 1970, it categorizes drugs into five schedules.
Step-by-step explanation:
The regulation that established the classification system for drugs with potential for abuse based on their risk of abuse and dependence is the Controlled Substances Act (CSA).
Passed by Congress in 1970, the CSA categorizes drugs into different schedules depending on their medical use, potential for abuse, and risk of dependence.
Drugs are placed into one of five schedules, with Schedule I drugs having the highest potential for abuse and no accepted medical use, and Schedule V having the lowest potential for abuse and greater accepted medical use.