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How many complementarity-determining regions contribute to the antigen-binding site in an intact T-cell receptor?

User Achint
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Final answer:

An intact T-cell receptor has six complementarity-determining regions (CDRs), with three CDRs on each of the two chains, that contribute to the antigen-binding site.

Step-by-step explanation:

The T-cell receptor (TCR) is comprised of two chains, each having a variable region that is essential for antigen binding. There are three complementarity-determining regions (CDRs) on each chain within the variable regions. These CDRs are hypervariable regions that contribute to the formation of the antigen-binding site. Therefore, an intact T-cell receptor has a total of 6 CDRs that determine its antigenic specificity, with three on each of the two chains (α and β chains).

User Guilherme Viebig
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