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During T-cell receptor _____-gene rearrangement, two D segments may be used in the final rearranged gene sequence, thereby increasing overall variability of this chain?

User Okutane
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Final answer:

In T-cell development, β-gene rearrangement can utilize two D segments to increase variability of the T-cell receptor β chain, which, along with the V and J segments' recombination orchestrated by DNA recombinase, contributes to the immune system's diverse antigen recognition capabilities.

Step-by-step explanation:

The question refers to the process known as T-cell receptor β-gene rearrangement, which occurs during T-cell development in the thymus.

In this process, gene segments called variable (V), diversity (D), and joining (J) segments undergo recombination to create the variable region of the T-cell receptor (TCR) β chain.

It is during this rearrangement that the genetic material can incorporate two D segments, which increases the overall variability of the β chain.

The presence of 52 different Vβ segments, two different Dβ segments, and 13 different Jβ segments allows for a multitude of potential V-D-J combinations, contributing to a vast array of TCR specificities capable of recognizing many different antigens.

Similarly, B cells utilize V, D, and J gene segments for the heavy chains of their receptors, and V and J gene segments for the light chains, to generate a large diversity of antibody molecules.

An enzyme called DNA recombinase plays a crucial role in excising and splicing these segments, enhancing the immune system's ability to respond to a myriad of microbial epitopes.

User Keeehlan
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