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In terms of V, D, and J segment arrangement, the T-cell receptor α-chain locus resembles the immunoglobulin _______ locus, whereas the T-cell receptor β-chain locus resembles the immunoglobulin _______ locus:

User Vmank
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Final answer:

The T-cell receptor α-chain locus resembles the immunoglobulin light chain locus due to its V and J segment arrangement, while the T-cell receptor β-chain locus is analogous to the immunoglobulin heavy chain locus because it includes V, D, and J segments.

Step-by-step explanation:

In terms of V, D, and J segment arrangement, the T-cell receptor α-chain locus resembles the immunoglobulin light chain locus, whereas the T-cell receptor β-chain locus resembles the immunoglobulin heavy chain locus.

The arrangement of V (Variable), D (Diversity), and J (Joining) segments is critical for creating the receptors that will identify and respond to a multitude of antigens. The TCR α-chain utilizes V and J rearrangement, mirroring the immunoglobulin light chain's genetic structure. On the other hand, the TCR β-chain employs V, D, and J rearrangements, which is analogous to the immunoglobulin heavy chain used in B cell receptors (BCRs).

B cells and T cells both undergo genetic rearrangements during their maturation in the bone marrow for B cells, and thymus for T cells, enabling a vast diversity in the antigen receptors they present. This genetic recombination allows the creation of many different antigen-binding sites, which render the immune system capable of recognizing an extensive range of microbial epitopes.

User Guoxin
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