Final answer:
The favored model of transport through the Golgi apparatus involves vesicles from the ER fusing with the cis face, modifying proteins and lipids, and then these being sorted and dispatched from the trans face.
Step-by-step explanation:
The Golgi apparatus is a complex cellular organelle responsible for modifying, sorting, and packaging proteins and lipids received from the endoplasmic reticulum (ER) before their distribution to various cellular destinations.
The Cisternal Maturation Model proposes that the Golgi cisternae are dynamic structures that mature over time. According to this model:
Vesicular transport: Proteins and lipids move through the Golgi apparatus via vesicles that shuttle between the different cisternae stacks. These vesicles transport cargo molecules both forward and backward within the Golgi stacks.
Cisternal maturation: The Golgi cisternae are not static; instead, they change and mature over time. Newly formed cisternae bud off from the ER and gradually move through the Golgi stacks. As they progress, they undergo modifications and maturation by acquiring specific enzymes and molecules from other Golgi compartments.
Retrograde transport: The model suggests that as a cisterna progresses forward through the Golgi stack, it matures and gradually transforms into the next stage. Meanwhile, the enzymes and molecules necessary for modifying cargo molecules move backward (retrograde transport) within the Golgi to earlier cisternae in vesicles.
Overall, the Cisternal Maturation Model proposes a dynamic process where Golgi cisternae mature and change composition as they progress, allowing for the sequential modification and sorting of proteins and lipids during their transit through the Golgi apparatus.