Final answer:
Not all Golgi glycotransferases used during N-linked glycosylation are located in the cis-Golgi; they are found in various compartments of the Golgi apparatus where they modify proteins at different stages. Option 2 false is correct.
Step-by-step explanation:
False, not all Golgi glycotransferases involved in N-linked glycosylation are located in the cis-Golgi. The Golgi apparatus is composed of different compartments: the cis-Golgi network, medial-Golgi, endo-Golgi, and trans-Golgi network. Each of these areas contains specialized enzymes that modify proteins during their transit. While initial steps of glycosylation may occur in the cis-Golgi, the process continues through each compartment. Glycotransferases function at various stages, adding carbohydrates as proteins move towards the trans-Golgi.
In the trans-Golgi, further modifications occur before the glycoproteins are sorted and packed into vesicles bound for their final destinations. Therefore, it is not accurate to say that all glycotransferases are confined to the cis-Golgi region. Each region has specific enzymes that modify proteins as they travel through the Golgi. The N-linked glycosylation process involves the addition of sugar molecules to proteins, and this modification occurs in the medial-Golgi and trans-Golgi regions of the Golgi apparatus.