Final answer:
Once a glycoprotein's folding is assisted by calnexin or calreticulin, it proceeds to the Golgi apparatus for terminal glycosylation, after which it is packaged into vesicles for distribution either inside or outside the cell.
Step-by-step explanation:
After calnexin or calreticulin binds to a newly synthesized glycoprotein and assists in its folding, the glycoprotein typically undergoes further modification in the Golgi apparatus. In the rough endoplasmic reticulum (RER), the initial stages of glycoprotein synthesis, including the addition of a core glycoside, take place.
As the glycoprotein travels through the Golgi vesicles, the process of terminal glycosylation continues, adding more sugars to the protein, therefore refining it. The glycoprotein is then packaged in secretory vesicles, which may either deposit their contents within the cell or fuse with the plasma membrane to release the glycoprotein to the cell exterior.