Final answer:
The Rh-negative woman with an Rh-positive partner is most likely to experience Rh incompatibility, which can lead to hemolytic disease of the newborn in subsequent pregnancies if she has been sensitized before.
Step-by-step explanation:
The nurse identifies the Rh-negative woman with an Rh-positive partner as the most likely to have a problem with Rh incompatibility with the fetus. This is because Rh factor incompatibility can cause hemolytic disease of the newborn (HDN). If the Rh-negative woman has previously been sensitized to Rh-positive blood, her immune system can produce anti-Rh antibodies. These antibodies can cross the placenta in a subsequent pregnancy with an Rh-positive fetus, potentially leading to the destruction of the fetus's red blood cells. Prevention is possible with the administration of Rh immunoglobulin (RhoGAM) to the Rh-negative mother during and after her first Rh-positive pregnancy.