Final answer:
The statement is true, as most adverse opioid events are preceded by increased sedation. Sedation levels increase due to the depressant effects of opioids, heightened when combined with drugs like benzodiazepines, which also depress the central nervous system.
Step-by-step explanation:
The correct answer to the question is A. True. Most adverse opioid events are indeed often preceded by an increased level of sedation. Prescription opioids, like OxyContin and other pain-relieving opioid drugs, are known to have sedative effects along with their pain-relieving properties. When they are taken in combination with other central nervous system depressants such as benzodiazepines, which include examples like alprazolam (Xanax®), diazepam (Valium®), and lorazepam (Ativan®), there is an increased risk of sedation and potential overdose. Benzodiazepines also sedate, induce sleep, prevent seizures, and relieve anxiety. Due to the enhanced sedating effect when mixed with opioids, it is advisable to avoid taking benzodiazepines concurrently with prescription opioids whenever possible.