Final answer:
The common drug combination used to reverse neuromuscular blockade is Neostigmine/Atropine. Neostigmine inhibits cholinesterase, increasing acetylcholine to counter neuromuscular blockers, and Atropine mitigates the associated muscarinic effects.
Step-by-step explanation:
In the context of reversing neuromuscular blockade, the drug combination that is commonly used is Neostigmine/Atropine. Neostigmine is a cholinesterase inhibitor that increases the amount of acetylcholine at the neuromuscular junction, which can outcompete the neuromuscular blocking agents and reverse their effects. Atropine is used in conjunction with Neostigmine to counteract the muscarinic effects of excess acetylcholine, such as bradycardia (slow heart rate).
The antidote to atropine poisoning is a muscarinic agonist, which competes with atropine at the muscarinic receptors. To counteract anaphylactic shock, Epinephrine is the drug of choice. Atropine acts by blocking the muscarinic acetylcholine receptors and reducing symptoms of nerve agent poisoning. Lastly, a drug that affects both divisions of the autonomic system will either bind to or block nicotinic receptors.