Final answer:
The initial symptom in systemic sclerosis is often swelling of the hands before other symptoms such as skin tightening, fingertip ulcers, and shortness of breath develop.
Step-by-step explanation:
The first symptom to occur in systemic sclerosis, also known as scleroderma, is typically swelling of the hands (B). This autoimmune disease can present with various symptoms, which may include skin thickening and tightening, ulcers on fingertips, and shortness of breath as it progresses. However, the initial manifestation often involves swelling, a sign that can precede the more recognizable skin changes.
Regarding potential related concerns, conditions such as systemic lupus erythematosus (SLE) can also lead to an array of symptoms including fatigue, skin lesions, and joint pain. Understanding the presentation of these symptoms is crucial for diagnosis and management of such autoimmune systemic diseases.