Final answer:
The best response for a new graduate nurse is to check the state's Nurse Practice Act to determine if post-graduate certification is needed to start an IV.
Step-by-step explanation:
The best response for a new graduate nurse who is unsure about the requirement for post-graduate certification to start an IV is A. Check the state's Nurse Practice Act. This act provides the legal scope of practice for nurses in the state and will have details on whether a special certification is required to perform specific skills such as IV insertion. It's crucial for nurses to adhere to their scope of practice to ensure patient safety and to avoid legal issues. It is not about taking the opportunity to practice the skill if it's not within the legal scope without proper certification (D), or outright refusing without checking the regulations (B). Contacting the school (C) might be helpful for advice, but the state's Nurse Practice Act will have the definitive answer.