Question

Which statement about receptor-mediated endocytosis of LDL particles is true?

a. LDL receptors in the plasma membrane associate with clathrin-coated pits.
b. LDL receptors are not involved in endocytosis.
c. LDL particles enter the cell through simple diffusion.
d. Clathrin-coated pits are not associated with endocytosis.

Answer 1

In receptor-mediated endocytosis, LDL receptors in the plasma membrane associate with clathrin-coated pits. This process allows for the uptake of LDL (low-density lipoprotein) particles. When receptor-mediated endocytosis is ineffective, LDL particles cannot be removed from the blood, leading to increased cholesterol levels.

Step-by-step explanation:

In receptor-mediated endocytosis, LDL receptors in the plasma membrane associate with clathrin-coated pits. This process allows for the uptake of LDL (low-density lipoprotein) particles. When receptor-mediated endocytosis is ineffective, LDL particles cannot be removed from the blood, leading to increased cholesterol levels. Familial hypercholesterolemia is a genetic disease caused by defective or missing LDL receptors, resulting in life-threatening levels of cholesterol in the blood.