Final answer:
The correct pharmacologic considerations before administering parenteral medications are that the drug will not be filtered through the liver, adverse effects may be more pronounced, and close monitoring of older adults and children for drug effects is necessary.
Step-by-step explanation:
Pharmacologic considerations a nurse should contemplate before administrating parenteral medications include whether the drug will bypass the liver since parenteral routes do not involve initial liver filtering, recognizing that the adverse effects of drugs can be more pronounced, and that certain populations such as older adults and children should be monitored more closely for drug effects due to variability in metabolism and potential for side effects.
Option b. 2, 3, 4 is correct, as parenteral routes bypass the liver, adverse effects can be more pronounced due to higher plasma levels of the drug, and close monitoring of older adults and children is needed to avoid toxicity and adjust doses appropriately.