Final answer:
Patients should rotate insulin injection sites to prevent lipohypertrophy, which affects insulin absorption and blood glucose control.
Step-by-step explanation:
A health care professional should tell a patient to rotate injection sites when self-injecting Regular insulin (Humulin) to prevent lipohypertrophy. Lipohypertrophy is a common complication that can occur due to the frequent injections of insulin into the same site, leading to the accumulation of fatty lumps under the skin. These lumps can interfere with insulin absorption, causing variable blood glucose control. Rotating injection sites helps ensure that insulin is absorbed properly, maintaining its efficacy in lowering blood glucose levels after consuming a meal rich in glucose.