Final answer:
Leonardo da Vinci uses one point perspective and positioning of figures to create a sense of space and depth in his painting The Last Supper.
Step-by-step explanation:
Leonardo da Vinci uses space and perspective in his painting The Last Supper to create a sense of depth and focus. He employs one point perspective by locating the vanishing point behind the head of Christ, drawing the viewer's attention to the center of the painting. The receding lines of the walls and the positioning of the figures also contribute to the sense of space and depth in the artwork.