Final answer:
M.C. Escher effectively uses the concept of space in his lithograph by creating reflections that add depth and challenge our perception of space.
Step-by-step explanation:
M.C. Escher effectively uses the concept of space in his lithograph by creating a reflection of a man sitting in a library in a mirrored ball held by a hand. By doing this, Escher creates a sense of depth and the illusion of an alternative reality within the artwork. The reflection in the ball adds a new dimension to the composition and challenges our perception of space.