Final answer:
Chronic Granulomatous Disease (CGD) patients have a defect in the NADPH oxidase system of phagocytic cells, which hampers their ability to kill ingested bacteria and leads to chronic inflammation.
Step-by-step explanation:
Chronic Granulomatous Disease (CGD) patients demonstrate a defect in the NADPH oxidase system of phagocytic cells, including neutrophils and macrophages, which prevents the production of superoxide radicals in phagolysosomes. This defect impairs the ability of phagocytes to kill ingested bacteria, leading to a chronic local inflammation called a granuloma. Common microorganisms that cause infections in CGD patients include Aspergillus spp., Staphylococcus aureus, Chromobacterium violaceum, Serratia marcescens, and Salmonella typhimurium.