Final answer:
Antidepressant drugs primarily act by blocking the reuptake of neurotransmitters.
Step-by-step explanation:
Antidepressant drugs primarily act by blocking the reuptake of neurotransmitters. This means that they prevent unused neurotransmitters from being transported back to the neuron, allowing the neurotransmitters to remain active in the synaptic cleft for longer periods of time. This increases the effectiveness of neurotransmitters, such as serotonin, in the brain and helps to alleviate symptoms of depression.