Final answer:
Increased resistance to ventilations in an intubated patient may indicate air escaping through a hole in the lung and filling the pleural space.
Step-by-step explanation:
Increased resistance to ventilations in an intubated patient with a bag-valve-mask unit may indicate that air is escaping through a hole in the lung and filling the pleural space (option B). This is known as a pneumothorax, which is a condition where air accumulates in the space between the lung and the chest wall. It can lead to difficulty in ventilating the patient effectively and can be life-threatening, requiring immediate medical attention.