Final answer:
America's foreign policy in the 1920s was defined by A) isolationism, where the nation sought to stay out of foreign entanglements and maintain its independence in international affairs.
Step-by-step explanation:
America's general foreign policy during the 1920s of avoiding political and economic entanglements with other countries is best characterized by option A. Isolationism.
The policy of isolationism refers to a nation's stance of staying out of foreign entanglements and deals, chiefly to avoid being drawn into international conflicts and wars. This was in line with the sentiment of the period post-World War I, where the predominant attitude was to refrain from getting involved in European affairs and maintain independence in decision-making.
While imperialism involved extending a country's power and influence through colonization or military force, and expansionism concerned broadening a nation's territory or influence, these do not reflect the U.S. attitude toward foreign policy in the 1920s which aimed at avoiding such engagements.
Similarly, interventionism, which would involve active interference in other countries' affairs, is quite the opposite of the isolationist approach America pursued during that era.